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In animals, fatty acid desaturases catalyze key reactions in the synthesis of arachidonic acid and other polyunsaturated fatty acids. A search of theCaenorhabditis elegans DNA databases, using the sequences ofArabidopsis genes, identified several putative desaturases. Here we describe the characterization of the first of these genes,fat-1 . The predicted protein encoded by afat-1 cDNA showed 32–35% identity with both FAD2 and FAD3 ofArabidopsis . When expressed in transgenic plants,fat-1 resulted in a 90% increase in the proportion of α-linolenic acid in root lipids. Wild-typeArabidopsis incorporated ω-6 fatty acids (Δ8,11,14–20:3 and Δ5,8,11,14–20:4) into membrane lipids but did not desaturate them. By contrast,fat-1 transgenic plants efficiently desaturated both of these fatty acids to the corresponding ω-3 products. These findings indicate that theC. elegans fat-1 gene encodes the first animal representative of a class of glycerolipid desaturases that have previously been characterized in plants and cyanobacteria. The FAT-1 protein is an ω-3 fatty acyl desaturase that recognizes a range of 18- and 20-carbon ω-6 substrates.

Identification of an animal ω-3 fatty acid desaturase by heterologous expression in Arabidopsis