Open AccessInitiation of meiotic recombination is independent of interhomologue interactions.
Author(s) -
Larry A. Gilbertson,
Franklin W. Stahl
Publication year - 1994
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.91.25.11934
Subject(s) - chromosomal crossover , meiosis , recombination , homologous recombination , double strand , genetics , biology , pairing , saccharomyces cerevisiae , yeast , microbiology and biotechnology , physics , dna repair , dna , gene , superconductivity , quantum mechanics
In yeast meiosis, crossing-over between homologues is dependent upon double-strand breaks. We demonstrate that the occurrence of these breaks is independent of pairing between homologues by showing that they occur with normal frequency, timing, and position in the absence of a homologue. This observation supports models that view double-strand breaks as initiating events and crossing-over as a consequence of repair of these breaks.