Open AccessCoatomer-rich endoplasmic reticulum.
Author(s) -
Lelio Orci,
Alain Perrelet,
Mariella Ravazzola,
M Amherdt,
James E. Rothman,
Randy Schekman
Publication year - 1994
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.91.25.11924
Subject(s) - endoplasmic reticulum , golgi apparatus , copi , microbiology and biotechnology , copii , chemistry , biology , secretory pathway
We identify in normal cells the existence of two distinct sites of the transitional endoplasmic reticulum (ER), one housing the Sec23p protein complex (the classical transitional element), the other the coatomer protein complex (the coatomer-rich ER). Experimental conditions that reduce transport from the ER to the Golgi complex lead to the overexpression of this newly defined coatomer-rich ER.