Open AccessIdentification of another member of the transforming growth factor type beta gene family.
Author(s) -
Peter ten Dijke,
Pamela F. Hansen,
Kenneth K. Iwata,
Christian Pieler,
J. Gordon Foulkes
Publication year - 1988
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.85.13.4715
Subject(s) - peptide sequence , amino acid , complementary dna , gene , biology , beta (programming language) , transforming growth factor beta , nucleic acid sequence , genetics , microbiology and biotechnology , signal transduction , programming language , computer science
We report here the complete amino acid sequence of another member of the type beta transforming growth factor gene family, deduced from the nucleotide sequence of three overlapping cDNA clones. The C-terminal 112 amino acids share approximately 80% sequence identity with type beta 1 and beta 2 transforming growth factors, with many of the remaining differences being conservative substitutions. By analogy to type beta 1 and type beta 2 transforming growth factors, we predict the protein to be synthesized as a 412 amino acid precursor that undergoes proteolytic cleavage to produce the mature polypeptide.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom