English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Inhibitory postsynaptic currents occurring spontaneously in the teleost Mauthner cell were analyzed with the single-electrode voltage-clamp technique. They were collected during depolarizing steps and were outward-going; this procedure allowed them to be isolated from possible excitatory currents flowing in the opposite direction. Their amplitude histograms were found to exhibit regularly spaced multiple peaks, each of which had a Gaussian distribution of the same width. These compound inhibitory postsynaptic currents represent responses evoked by background firing of presynaptic neurons, and when tetrodotoxin was applied topically, only the first peak in the frequency histogram, which can be attributed to single exocytotic events, remained. The mean conductance of this quantal unit equalled 46.0 nS, which corresponds to the opening of 1000-2000 Cl- channels activated by glycine--the transmitter at these synapses. Its waveform and those of the larger units were essentially the same. Furthermore, in each set of data provided by a given Mauthner cell, the size of a quantum was quite constant, with its variance and those of further peaks being equivalent to that of background noise. These properties, which characterize the quantal events on the basis of spontaneous synaptic activity, were strikingly similar to those of the basic units derived by the simple binomial to those of the basic units derived by the simple binomial analysis of unitary postsynaptic potentials, thus validating the use of this statistical model to quantify the quantal nature of release at central connections. The quite straightforward method used here to extract single miniature currents from complex signals should be applicable to the other systems of the central nervous system, where the pertinence of this probabilistic model of release has yet to be demonstrated.

Spontaneous quantal currents in a central neuron match predictions from binomial analysis of evoked responses.