Open AccessTheoretical treatment of microtubules disappearing in solution.
Author(s) -
Y Chen,
Terrell L. Hill
Publication year - 1985
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.82.12.4127
Subject(s) - microtubule , physics , biophysics , chemistry , statistical physics , biology , microbiology and biotechnology
The origin of the two-phase (cap, no cap) macroscopic kinetic model of the end of a microtubule is reviewed. The model is then applied to a new theoretical problem, namely, the Mitchison-Kirschner [Mitchison, T. & Kirschner, M. W. (1984) Nature (London) 312, 237-242] experiment in which aggregated microtubules in solution spontaneously decrease in number (shorten to disappearance) while the surviving microtubules increase in length. The model fits the experiments without difficulty.
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