Open AccessStructure of a human gastrin gene.
Author(s) -
Ove Wiborg,
Lars Berglund,
Esper Boel,
Fanny Norris,
Kjeld Norris,
Jens F. Rehfeld,
Kjeld A. Marcker,
Jens Vuust
Publication year - 1984
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.81.4.1067
Subject(s) - gastrin , gene , coding region , genetics , base pair , biology , start codon , regulatory sequence , sequence (biology) , microbiology and biotechnology , regulation of gene expression , base sequence , biochemistry , secretion
A gastrin gene was isolated from a genomic library of human DNA. The human gastrin gene is about 4100 base pairs long and contains two intervening sequences. Thus, a 3500-base-pair intervening sequence is located 5 base pairs proximal to the ATG initiator codon, while a 129-base-pair intervening sequence separates the region coding for the principal hormonal form of gastrin, the heptadecapeptide, from the region coding for the major amino-terminal portion of the gastrin precursor. The 5' flanking region of the gene contains the conserved sequences, T-A-T-A-A and G-A-C-T-C-A-T-A-T, in positions similar to those of other eukaryotic genes.
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