English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The ontogeny of Ia-bearing accessory cells was studied in mice. Ia-bearing adherent cells from the thymus, consisting predominantly of macrophages, were found from birth. These adherent cells were able to present antigen, as measured by their ability to induce immune T-cell proliferation. In contrast, Ia-bearing adherent cells from the spleen were not found until the second week of life, and their antigen-presentation function was not present until later. The differential ontogeny of Ia-bearing accessory cells at these sites may be important in both development of immune competence and the restriction of autoimmunity.

During ontogeny, Ia-bearing accessory cells are found early in the thymus but late in the spleen.