Open AccessDeficiency in histone acetylation in nontransforming host range mutants of polyoma virus.
Author(s) -
Brian Schaffhausen,
T L Benjamin
Publication year - 1976
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.73.4.1092
Subject(s) - acetylation , histone , mutant , host (biology) , virus , simian , biology , microbiology and biotechnology , chemistry , virology , biochemistry , genetics , dna , gene
Histones H3 and H4 derived from transforming wild-type polyoma and simian virus 40 particles show extensive acetylation compared to the histones of the host cells. The same histone fractions derived from nontransforming host range mutants of polyoma virus fail to show this high degree of acetylation.
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