Open AccessSympathetic Reinnervation of the Rat Iris in Organ Culture
Author(s) -
Stephen D. Silberstein,
David G. Johnson,
David M. Jacobowitz,
Irwin J. Kopin
Publication year - 1971
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.68.6.1121
Subject(s) - reinnervation , iris (biosensor) , superior cervical ganglion , ganglion , plexus , anatomy , cervical ganglia , immunohistochemistry , biology , nerve growth factor , denervation , norepinephrine , sympathetic ganglion , organ culture , sympathetic innervation , in vitro , neuroscience , endocrinology , dopamine , biochemistry , receptor , computer security , computer science , biometrics , immunology
Reinnervation of sympathetically denervated rat iris by superior cervical ganglion cells has been demonstrated to occur in vitro. Return of [(3)H]norepinephrine uptake by irises incubated in contact with ganglia was associated with the reappearance of nerve fibers containing catecholamines that were demonstrable by fluorescent histochemistry. The reinnervating neurons appeared to follow the same general pattern of innervation seen in the normal iris, but the density of the neural plexus was much greater. Nerve growth factor influenced the rate and extent of innervation of the iris but not of neuronal growth within the ganglion.
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