Open AccessTransformation of Hamster Cells In Vitro by Polycyclic Hydrocarbons without Cytotoxicity
Author(s) -
Joseph A. DiPaolo,
Paul Donovan,
Richard L. Nelson
Publication year - 1971
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.68.12.2958
Subject(s) - pyrene , carcinogen , anthracene , cytotoxicity , hamster , chemistry , in vitro , methylcholanthrene , transformation (genetics) , alpha (finance) , chinese hamster , biochemistry , benzopyrene , benzo(a)pyrene , stereochemistry , microbiology and biotechnology , organic chemistry , biology , gene , nursing , construct validity , medicine , patient satisfaction
Treatment with either a flavone or benz(alpha)anthracene before the addition of a potent carcinogen, benzo(alpha)pyrene or 3-methylcholanthrene, enhanced the transformation of Syrian hamster cells that are seeded in order to form colonies. 7,8-benzoflavone and benz(alpha)anthracene prevented the cytotoxicity by the carcinogens, while 5,6-benzoflavone did not. The results clearly indicate that it is possible to dissociate the transforming from the toxic metabolic properties of benzo(alpha)pyrene and 3-methylcholanthrene.
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