Open AccessProduction of Albumin and Other Serum Proteins by Clonal Cultures of Normal Human Liver
Author(s) -
M. Edward Kaighn,
Alfred M. Prince
Publication year - 1971
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.68.10.2396
Subject(s) - clone (java method) , biology , cell culture , secretion , albumin , cell , human liver , human serum albumin , ploidy , human albumin , microbiology and biotechnology , function (biology) , serum albumin , antigen , biochemistry , immunology , genetics , gene , in vitro
Clonal cell strains have been isolated from normal human liver. These cells, while resembling fibroblasts morphologically, function as hepatocytes, as shown by their ability to synthesize and secrete an antigen identical to human serum albumin. Human diploid and aneuploid cell lines from nonliver sources do not exhibit this property. The spectrum of serum proteins synthesized varied from clone to clone and cell line to cell line.
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