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Evidence is presented for the existence of a conformational equilibrium in staphylococcal nuclease, involving one out of the four histidines and none of the other aromatic residues in the polypeptide chain.

proceedings of the national academy of sciences of the united states of america

Nuclear Magnetic Resonance Studies of the Structure and Binding Sites of Enzymes, XII. A Conformational Equilibrium in Staphylococcal Nuclease Involving a Histidine Residue