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In this paper, Anfinsen, Schecter, and Moravek described the modification of a technique for the study of hydrogen exchange in proteins that was previously developed by Aase Hvidt and Kaj Linderstrom-Lang and which allowed the researchers to study the interactions of proteins with various ligands and of the polypeptide chains with each other. The paper was produced at a time when the primary concern of Anfinsen's laboratory was to understand the relationship between structure and function in staphylococcal aureus.

Suppression of hydrogen exchange in staphylococcal nuclease by ligands.