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The heterogeneity of the cell population of antibody-producing tissues poses a potentially serious problem in attempts to devise a cell-free system in which the primary interest is to study immunoglobulin synthesis. Since it is believed that proteins intended for excretion are synthesized mainly, if not exclusively, on the membrane-bound ribosomes of the endoplasmic reticulum (ER), and since this reticulum is much better developed in plasma cells than in most other lymphoid cells, it was decided to select the ER membranes of lymph nodes as a protein-synthesizing fraction. This paper shows that it is indeed possible to prepare from lymph nodes a cell fraction consisting almost exclusively of ER microsomal vesicles, which is, in optimal conditions, as active in cell-free protein synthesis as systems derived from liver. A subsequent paper will report the cell-free synthesis, by this cell fraction, of immunoglobulin with antibody activity.1

Studies on cell-free synthesis of rat immunoglobulins, I. A cell-free system for protein synthesis prepared from lymph-node microsomal vesicles.