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Conditional lethal mutants have been shown to be extremely useful in the study of the physiology of viral reproduction and maturation.1,2 Since such mutants are distributed over most of the genetic map,1,2 they could prove to be valuable in the study of tumor viruses. They may be used to “tag” almost all of the viral genes, a property of obvious physiological and genetical implication; they can also be useful for studying the mechanisms by which these viruses transform normal cells into cancer cells. For instance, it may be possible to determine, on one hand, which viral functions are needed for the initiation of cell transformation and, on the other hand, which functions are essential for the maintenance of the transformed state. Furthermore, these mutants allow the use of selective techniques and thus provide a sensitive tool for performing marker rescue experiments to find out whether any of the genes of the transforming virus persist in the transformed cells.

CELL-TRANSFORMING ABILITY OF A TEMPERATURE-SENSITIVE MUTANT OF POLYOMA VIRUS