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The practical and theoretical importance of attempts to isolate and characterize histocompatibility antigens is well recognized. The availability of purified antigenic materials should allow more precise methods for analyzing the mechanisms of such complex phenomena as homograft rejection, acquired immunological tolerance, and immunological enhancement. Furthermore, a knowledge of the tissue distribution and cellular localization of particular antigens may provide an insight into the normal physiological significance of these substances which have been detected primarily because of their untoward influence in the homotransplantation of tissues. The murine lymphoblast L-5178Y, a cell line that can be grown on a large scale in tissue culture, has been shown to be a convenient starting material for the isolation of mouse histocompatibility antigens. Previous reportsl 2 indicated that a soluble fraction prepared from sonic lysates of L-5178Y could sensitize mice of an homologous strain to show an accelerated rejection of grafts of tumor cells. The soluble material also caused an accelerated rejection of tail skin homografts but did not affect the survival time of orthotopically placed skin homografts. The antigens affecting the latter were found in the particulate fractions of the cells. This report describes the isolation of an antigenic fraction from homogenates of L-5178Y which will cause an accelerated rejection of skin homografts as well as of tumor grafts, and which will also combine with the hemagglutinating and cytotoxic antibodies of mouse isoimmune sera. The antigenic activities were found to be associated with the high density lipoproteins of the cell.

IN VIVO AND IN VITRO STUDIES OF HISTOCOMPATIBILI ANTIGENS ISOLATED FROM A CULTURED MOUSE CELL LINE