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ho, then runs along the To-axis to (0, 0, 0), and then has a final segment parallel to the final segment of ho). It is easily seen that, given any cal < a2 < ... < an < W,£ then D*a,, ...,an, wi (ho, ho) = 0 for 0 > an. On the other hand, in any homeomorphism of the bases of ho, he, the points (w,, 0) of each base must correspond, whence D,(ho, he) = 1, all a < wi. Thus ho is in the closure of the family (h0) with respect to U* but not with respect to U.

A NERVE GROWTH-STIMULATING FACTOR ISOLATED FROM SARCOM AS 37 AND 180