Open AccessBase pair analogs in the gas phase
Author(s) -
Joseph Roscioli,
David W. Pratt
Publication year - 2003
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2333806100
Subject(s) - dihedral angle , chemistry , base pair , hydrogen bond , moment of inertia , gas phase , dimer , base (topology) , crystallography , phase (matter) , bond length , thymine , stereochemistry , molecule , crystal structure , physics , dna , mathematical analysis , organic chemistry , quantum mechanics , biochemistry , mathematics
A rotationally resolved electronic spectrum of the gas-phase dimer 2-aminopyridine.2-pyridone, an analog of the adenine.thymine base pair, has been observed and assigned, leading to precise measurements of its moments of inertia and preliminary determinations of its structure. A Watson-Crick configuration results, with N...H-N and N-H...O hydrogen bond lengths of 2.898 and 2.810 A, respectively. The two bases are found not to be coplanar; a dihedral angle of 6.1 degrees between the base planes is also estimated from the measured moments of inertia. Possible chemical and biological implications of these results are discussed.
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