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Significance Activation of brown adipose tissue offers a strategy for enhancing energy expenditure to counteract obesity and other metabolic disorders. The discovery of novel factors regulating brown adipose tissue function has implications in therapeutic intervention to treat metabolic dysfunction. Here, we discover a previously uncharacterized RNA binding protein called FAM195A and show that genetically engineered mice lacking FAM195A are severely cold intolerant and have abnormalities in branched-chain amino acid metabolism. In vitro studies showed that FAM195A is required for the expression of enzymes involved in branched-chain amino acid catabolism. This study reveals FAM195A to be a link between thermoregulation, metabolism, and RNA processes, highlighting FAM195A as an important regulator of brown adipose tissue activation.

Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A