English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Significance Long interspersed element class 1 (LINE1 ) elements are transposable elements that comprise ∼20% of mammalian genomes. Their activity must be tightly controlled or genome integrity will be compromised, leading to DNA damage and cell death. Here, we report that several members of a rapidly evolving X-linked homeobox gene cluster suppressLINE1 transposition. One family member of thisRhox gene cluster—Rhox10 —silencesLINE1 expression and transposition in the male germline when it is hypomethylated and thus highly susceptible toLINE1 activation.Rhox10 acts by driving the expression ofPiwil2 , which encodes a key component in the Piwi-interacting RNA pathway. The ability ofRhox genes to suppressLINE1 elements is evolutionarily conserved and perturbed by mutation in infertility patients.

The Rhox gene cluster suppresses germline LINE1 transposition