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Significance NontypeableHaemophilus influenzae (NTHi) is a common cause of localized respiratory tract disease and results in significant morbidity in children and adults, prompting interest in developing a vaccine to prevent NTHi disease. It has been challenging to date to develop a vaccine that has broad activity against diverse NTHi strains. In this work, we found that immunization of mice with the NTHi HMW1 and HMW2 adhesive proteins stimulates protective immunity against nasopharyngeal colonization by genetically distinct NTHi strains. This immunity includes a strain-specific antibody response and a broadly protective cell-mediated response. Our results highlight the vaccine potential of the HMW1 and HMW2 proteins.

Immunization with HMW1 and HMW2 adhesins protects against colonization by heterologous strains of nontypeable Haemophilus influenzae