Open AccessA class of independently evolved transcriptional repressors in plant RNA viruses facilitates viral infection and vector feeding
Author(s) -
Lulu Li,
Hehong Zhang,
Changhai Chen,
HaiJian Huang,
Xiaodong Tan,
Zhongyan Wei,
Junmin Li,
Fei Yan,
ChuanXi Zhang,
Jianping Chen,
Zongtao Sun
Publication year - 2021
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.2016673118
Subject(s) - biology , repressor , viral evolution , genetics , transcriptional regulation , transcription (linguistics) , rna , virology , computational biology , transcription factor , gene , linguistics , philosophy
Significance To accomplish the infection cycle, plant viruses usually employ various pathogenic factors to inhibit host antiviral defense. Revealing pathogenic mechanisms conserved among different viruses is essential for developing broad-spectrum disease control. Here, we show that a class of independently evolved transcriptional repressors is widely present in different plant viruses. Despite the diverse sequences and different evolutionary origins, these transcriptional repressors all modulate JA signaling by inhibiting the transcriptional activation of OsMYC transcription factors, disassociating the OsMED25-OsMYC complex, and cooperating with OsJAZ to improve their transcriptional repression activity. This facilitates viral infection and enhances vector feeding. Our findings reveal key functions of the transcriptional repressors in plant viruses and shed light on the general mechanism of viral pathogenicity and vector transmission.