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We recently reported that the nonclassical HLA class I molecule HLA-G was expressed in the endomyocardial biopsies and sera of 16% of heart transplant patients studied. The aim of the present report is to identify cells that may be responsible for HLA-G protein expression during the allogeneic reaction. Carrying out mixed lymphocyte cultures in which the responder cell population was depleted either in CD4(+) or CD8(+) T cells, we found that soluble HLA-G5 protein but not the membrane-bound HLA-G isoform was secreted by allo-specific CD4(+) T cells from the responder population, which suppressed the allogeneic proliferative T cell response. This inhibition may be reversed by adding the anti-HLA-G 87G antibody to a mixed lymphocyte culture. That may indicate a previously uncharacterized regulatory mechanism of CD4(+) T cell proliferative response.

proceedings of the national academy of sciences of the united states of america

Soluble HLA-G protein secreted by allo-specific CD4<sup>+</sup>T cells suppresses the allo-proliferative response: A CD4<sup>+</sup>T cell regulatory mechanism

Soluble HLA-G protein secreted by allo-specific CD4+T cells suppresses the allo-proliferative response: A CD4+T cell regulatory mechanism

Soluble HLA-G protein secreted by allo-specific CD4⁺T cells suppresses the allo-proliferative response: A CD4⁺T cell regulatory mechanism