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The Letter by Semelidou and Skoulakis (1) questions the congruence of our model (2) with current experimental evidence of olfactory habituation. We thank the authors for their Letter and would like to make three points in response. 1) Re: “and is independent of the mushroom bodies, unlike what the authors propose.”To clarify, our model studied the effect of antennae lobe (AL) habituation on the mushroom body (MB) downstream. We did not propose that 30-min habituation itself occurs in, or requires, the MB. Indeed, we directly followed the mechanism proposed by … [↵][1]1To whom correspondence may be addressed. Email: navlakha{at}cshl.edu. [1]: #xref-corresp-1-1

Reply to Semelidou and Skoulakis: “Short-term” habituation has multiple distinct mechanisms