English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Significance Combining DNMTi with PARPi induces HRD in a BRCA-proficient setting. We now uncover an unexpected mechanism for generation of HRD that joins drug induction of a broad, innate immune signaling to directly drive HRD. The findings have important translational implications for broadening the scope of PARPi therapy and potentially for immunotherapy.

Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency