Open AccessSOX4-mediated repression of specific tRNAs inhibits proliferation of human glioblastoma cells
Author(s) -
Jianjing Yang,
Derek K. Smith,
Haoqi Ni,
Ke Wu,
Dongdong Huang,
Sishi Pan,
Adwait Amod Sathe,
Yu Tang,
Meng-Lu Liu,
Chao Xing,
ChunLi Zhang,
Qichuan Zhuge
Publication year - 2020
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.1920200117
Subject(s) - rna polymerase iii , biology , ectopic expression , cell growth , gene , microbiology and biotechnology , chromatin , translation (biology) , chromatin immunoprecipitation , translational regulation , gene expression , rna , genetics , messenger rna , promoter , rna polymerase
Significance Transfer RNAs (tRNAs) are essential for mRNA translation and protein synthesis. Their expression is tightly associated with cell states and is broadly controlled by the recruitment of Pol III through intragenic elements. Whether and how tRNA genes could also be individually regulated is not known. In this study, our results reveal that a polymerase II-dependent DNA-binding transcription factor can also regulate the expression of specific tRNAs through direct binding to DNA elements surrounding the tRNA genes. Such a regulatory mode may have broader implications into understanding how cells coordinate mRNA translation and codon usage with cell state and behavior, such as proliferation and reprogramming of human glioblastoma cells.
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