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Significance Antigen receptor genes are assembled during lymphoid development from gene fragments by the process known as variable (diversity) joining (V[D]J) recombination. This process, which is initiated by the RAG1/RAG2 recombinase, is fundamental to the generation antigen receptor diversity required to respond to a virtually limitless array of pathogens. We show that chromatin at antigen receptor loci is subject to change during lymphoid development. We hypothesize that these developmentally regulated alterations of chromatin state may help to guide RAG1/RAG2 to the correct sites in recombinationally active cells. These changes represent key features of antigen receptor genes during lineage progression, serving either to facilitate or to impose a barrier to V(D)J recombination depending on cell lineage and developmental stage.

Alterations in chromatin at antigen receptor loci define lineage progression during B lymphopoiesis