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Significance It has been demonstrated that a diverse set of enzyme-mediated chemical modifications are found within RNAs, and these modifications markedly influence the fate of RNAs in cells. Dysregulation of such RNA modifications is involved in the development of a battery of human disorders. Studies to date have focused solely on individual modifications on isolated RNA; however, RNA modifications exist concurrently in multiple RNA species. Using biochemistry and high-throughput sequencing techniques, we revealed an interaction between a transfer RNA methyltransferase TRMT10A and a messenger RNA demethylase FTO, which influences the methylation levels on a subset of messenger RNAs. This study unravels a regulatory mechanism by which methylations across distinct RNA types are coordinated to impact gene expression collaboratively.

Coordination of mRNA and tRNA methylations by TRMT10A