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Significance Ribosomes—the universal biosynthesis machinery central to all cellular life—are composed of 4 ribosomal RNA (rRNA) and up to 80 ribosomal proteins (RPs), yet detecting fluctuations in their RP composition with possible functional consequences remains a challenge. Using quantitative proteomics we show an invariant RP composition of ribosomes across 3 murine brain and liver tissues. The RP pool does not change with age and remains constant in tissues of juvenile, adult, and middle-aged mice groups. In a broader context, the high robustness in the overall protein architecture of the ribosomes across tissues and ages implies that ribosomal heterogeneity, if any, may result from other processes, including postsynthesis modifications of rRNA and RPs.

Invariable stoichiometry of ribosomal proteins in mouse brain tissues with aging