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Significance Cancer is associated with low-oxygen cellular environments. However, a better understanding of the connection between the amount of oxygen in a cell’s microenvironment and its behavior is much needed. By optical measurements, we have characterized how the redox chemistry and the intracellular redox potential of cells respond to changes in oxygen pressure. Through surprisal analysis (a technique based on thermodynamics), we were able to identify changes in cellular signaling molecules (microRNAs [miRNAs]) that correlate with redox changes and found that, at low-oxygen conditions, these miRNAs are associated with tumor spread and survival. The changes in miRNA expression were used to quantify the free-energy variations with oxygen pressure, variations that reflect the changes in the measured intracellular redox potential.

Intracellular redox potential is correlated with miRNA expression in MCF7 cells under hypoxic conditions