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Significance Animals need to quickly extract the valence information of sensory stimulus and assess whether the stimulus is attractive or aversive. Deciphering the molecular and circuit mechanisms that determine the stimulus valence is fundamental to understand how the nervous system generates the animal behaviors. Here we report that the AFD thermosensory neurons ofC. elegans evoke in its postsynaptic AIY interneurons opposing neuronal responses that correlate with the valence of thermal stimuli. TheC. elegans homologs of MAST kinase, Stomatin, and Diacylglycerol kinase function in AFD and regulate the opposing AIY responses. Our results further suggest that the alteration between excitatory and inhibitory AIY responses is mediated by controlling the balance of two opposing signals released from the AFD neurons.

Presynaptic MAST kinase controls opposing postsynaptic responses to convey stimulus valence in Caenorhabditis elegans