English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Cells respond to the mechanical properties of their environment, altering a range of cellular functions important to normal tissue function, disease progression, and repair. This mechanosensing ability has been studied predominantly with planar substrates which, while experimentally advantageous, do not capture the complexity of cellular interfaces. This report demonstrates that T cells respond to the mechanical resistance of microfabricated elastomer structures, identifying an aspect of mechanosensing that has implications from understanding cell–cell interactions to design of biomaterials.

T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces