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Significance Prior to their exposure to foreign antigens, naïve T cells experience weak T cell antigen receptor (TCR) signals induced by self-antigens. These “basal” TCR signals vary in strength, which is reflected by the relative expression of markers such as CD5, Ly6C, and Nur77-GFP. Using a combination of Nur77-GFP and Ly6C, we show that the range of basal TCR signaling is broader than previously thought. A population of cells at the high end of this range experiences relatively strong basal TCR signals and attenuated responses to foreign antigen stimulation. These results suggest that T cells adapt to the strength of their basal TCR signaling, which results in heterogeneity of their functional capabilities following stimulation with foreign antigens.

Adaptation by naïve CD4 + T cells to self-antigen–dependent TCR signaling induces functional heterogeneity and tolerance

Adaptation by naïve CD4 ⁺ T cells to self-antigen–dependent TCR signaling induces functional heterogeneity and tolerance