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Significance Low levels of leptin, a hormone secreted by adipocytes that signals the body as to the availability of fuel stores, are known to increase food intake. Here, we demonstrate a mechanism by which low leptin stimulates food intake in rodents: Under conditions of hypoleptinemia, stress hormone (glucocorticoid) production is increased, and in turn stimulates AgRP neurons to promote appetite.

Leptin’s hunger-suppressing effects are mediated by the hypothalamic–pituitary–adrenocortical axis in rodents