English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Dramatic and rapid changes in transcription take place upon heat shock (HS), where thousands of genes have been shown to be immediately up- or down-regulated in metazoans. The role of large-scale chromatin conformation and changes in long-range interactions between distal regulatory elements and HS-regulated promoters remains unclear. Our study shows that topologically associating domains and compartment structures remain remarkably unchanged upon acute HS in human andDrosophila , while only modest changes of distal regulatory interactions are observed in human cells. These results suggest that the global chromatin structure required for the HS response is preestablished across metazoans in order to drive transcriptional changes in HS responsive genes.

Chromatin conformation remains stable upon extensive transcriptional changes driven by heat shock