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Significance DNA repair is essential for accurate maintenance of genetic information in all types of cells, but what regulatory mechanisms act on the complexes involved in this process has been unclear. The structural maintenance complex 5/6 (SMC5/6) associates with chromosomes under normal conditions and is recruited to DNA double-strand breaks for repair. However, the mechanism by which this conserved complex becomes dissociated from its original chromosomal location during DNA repair is completely unknown. Here, we describe a mechanism in which the chromosomal dissociation of SMC5 in plant cells is mediated via SWI3B, a subunit of the SWI/SNF complex. Given that these proteins are evolutionarily conserved, the current findings may provide hints for the study of DNA repair in other species.

A SWI/SNF subunit regulates chromosomal dissociation of structural maintenance complex 5 during DNA repair in plant cells