English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Significance Cell surface exposure of phosphatidylserine (PtdSer) is observed not only in apoptotic cells, but also in activated lymphocytes, activated platelets, capacitated sperm, aged erythrocytes, and some cancer cells. Xkr8, a membrane protein carrying 10 putative transmembrane segments, was originally identified as a scramblase that is activated by caspase-mediated cleavage during apoptosis. Here we show that mouse Xkr8 scramblase activity can be stimulated by kinase-mediated phosphorylation independent of the caspase-mediated cleavage, suggesting that Xkr8 may play a role in various biological processes to expose PtdSer.

Phosphorylation-mediated activation of mouse Xkr8 scramblase for phosphatidylserine exposure