English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Loss of insulin receptors in the brain causes metabolic and behavioral abnormalities whereas loss of IGF-1 receptors in the brain leads to a developmental defect in the brain and periphery. However, less is known about the impact of brain insulin and IGF-1 receptor (IR/IGF1R) loss in adult mice, especially in higher neural processing regions. Here, we show that loss of IR/IGF1R in the hippocampus and central amygdala of adult mice results in decrease in glutamate receptors, accompanied by glucose intolerance, anxiety-like behavior, and impaired cognition. In addition, we identify an insulin/IGF-1 signaling-dependent neural circuit originating from the central amygdala, which regulates interscapular brown fat activity and thermogenesis. Thus, brain insulin/IGF-1 signaling is important for higher neural processing and systemic metabolism.

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior