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Significance The diverse antifreeze proteins enabling the survival of different polar fishes in freezing seas offer unparalleled vistas into the breadth of genetic sources and mechanisms that produce crucial new functions. Although most new genes evolved from preexisting genic ancestors, some are deemed to have arisen from noncoding DNA. However, the pertinent mechanisms, functions, and selective forces remain uncertain. Our paper presents clear evidence that the antifreeze glycoprotein gene of the northern codfish originated from a noncoding region. We further describe the detailed mechanism of its evolutionary transformation into a full-fledged crucial life-saving gene. This paper is a concrete dissection of the process of a de novo gene birth that has conferred a vital adaptive function directly linked to natural selection.

Molecular mechanism and history of non-sense to sense evolution of antifreeze glycoprotein gene in northern gadids