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Significance Zika virus (ZIKV) has reemerged recently to cause serious human disease. However, there is no licensed vaccine or treatment currently available for ZIKV infections. Potently neutralizing antibodies are of interest due to their prophylactic and therapeutic potential. Here, we show that ZIKV-195, a potently neutralizing human monoclonal antibody, has postexposure therapeutic activity against ZIKV infection in a mouse model. We further describe the near-atomic resolution structure of the ZIKV virion in complex with ZIKV-195 Fab fragments and suggest a neutralization mechanism.

Structural basis of a potent human monoclonal antibody against Zika virus targeting a quaternary epitope