English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Outbreaks of Ebola virus disease (EVD) continue to emerge with severe and often deadly outcomes and global consequences. Novel strategies for examining host response differences that distinguish EVD survivors and fatalities can only deepen our understanding of the disease and expand diagnostic and treatment options. Lipids are major molecular constituents in human plasma with important structural, transport, energy, and signaling functions. Here we provide a comprehensive examination of the EVD lipidome. Using liquid chromatography tandem mass spectrometry, we profiled the human plasma lipidome of patients that survived and succumbed to EVD during the 2014 outbreak in Sierra Leone. The results highlight the profound impact of EVD on the host lipidome, leading to possible therapies for improving EVD survival.

Plasma lipidome reveals critical illness and recovery from human Ebola virus disease