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Significance This study investigates the sexually dimorphic development of innervation in mouse gonads. Neural crest-derived neurons invade the dorsal surface of the mouse ovary during embryonic development and give rise to a neural network, whereas in males, innervation is restricted to the surface of the testis. We propose a molecular mechanism regulating sexual dimorphism in this aspect of gonad development. Growing evidence indicates that neural crest cells can instruct patterning of their target organs during development, independently of their role in the adult organ. The structure and developmental timeline of male and female innervation established in this study lay the groundwork for characterization of functional interactions between neural and other cell types during gonad and duct patterning.

Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development