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Significance A potassium current in the heart (I Ks ) is important in regulating the heartbeat. These channels, composed of KCNQ1 and KCNE1 subunits, have four voltage-sensitive components and a pore component, which opens to allow current to pass through. The number of voltage-sensitive components required to activate to allow the pore to open has been debated extensively. While some believe all four are needed, others believe the pore can open with movement of a single voltage-sensitive component. Here, we show that the latter idea is correct, with movement of each component resulting in increasingly more current. This makes for a uniquely flexible channel, tunable for a broad range of responses.

I Ks ion-channel pore conductance can result from individual voltage sensor movements

I _Ks ion-channel pore conductance can result from individual voltage sensor movements