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Significance At fertilization, repetitive calcium signals are induced in mammalian eggs that are essential for activating embryo development. These signals are supported by calcium influx from the surrounding medium. Two ion channels supporting calcium influx into eggs, CaV 3.2 and TRPV3, were identified previously. Here we find that a third channel, TRPM7, is essential for this function. In the absence of both TRPM7 and CaV 3.2, the calcium signals induced by the fertilizing sperm stop prematurely. Female mice carrying eggs lacking TRPM7 and CaV 3.2 are subfertile. Because TRPM7 channel function is modulated by ions in culture medium, these findings highlight the importance of exact culture medium composition used during laboratory procedures for human assisted reproduction therapies.

TRPM7 and Ca V 3.2 channels mediate Ca 2+ influx required for egg activation at fertilization

TRPM7 and Ca _V 3.2 channels mediate Ca ²⁺ influx required for egg activation at fertilization