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Significance Environmental temperature acclimation is essential to animal survival, yet thermoregulation mechanisms remain poorly understood. In this study, we describe Ca2+ -dependent endoribonuclease (EndoU) ENDU-2 located in ADL chemosensory neurons and specific muscle cells as a regulator of multiple pleiotropic phenomena including cold tolerance, life span, and brood size through cell-autonomous and cell-nonautonomous pathways in nematodeCaenorhabditis elegans . Ca2+ imaging revealed ADL temperature response to be the result of transient receptor potential (TRP) channel activity and regulated by ENDU-2 via cell-autonomous and cell-nonautonomous pathways. Transcriptome analysis revealed that ENDU-2 influences expression of the caspase geneced-3 . Moreover, ENDU-2 downregulates cold tolerance and synaptic remodeling in the dorsal nerve cord through caspase signaling. We therefore propose a model for cold tolerance regulation that occurs via EndoU action.

proceedings of the national academy of sciences of the united states of america

Endoribonuclease ENDU-2 regulates multiple traits including cold tolerance via cell autonomous and nonautonomous controls in <i>Caenorhabditis elegans</i>

Endoribonuclease ENDU-2 regulates multiple traits including cold tolerance via cell autonomous and nonautonomous controls in Caenorhabditis elegans