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Significance Although millions of procedures are performed under general anesthesia every year, we do not fully understand the mechanisms underlying anesthesia. Orexin neurons in the hypothalamus form one of the centers in the central nervous system involved in sleep–wake control. The orexin system has also been implicated in anesthesia. In this study, we specifically activated orexin neurons via a designer receptor that is exclusively activated by a designer drug, to test how activation of orexin neurons affects anesthesia recovery. We found that orexin neuronal activation can speed up wakeup and improve pain control as well. Our study suggests that the orexin system has the potential as a target for drug discovery to facilitate postprocedural recovery.

Activation of orexin system facilitates anesthesia emergence and pain control