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Significance Sprouty (Spry) molecules are known regulators of the Erk signaling pathway. We determined how the absence of Spry 1 and Spry 2 affects the formation and function of effector and memory CD8+ T cells. We found that absence of Spry1/2 enhances the survival of effector CD8+ T cells and results in the formation of more polyfunctional memory cells. As increased numbers of memory CD8+ T cells strongly correlate with enhanced protection against tumors and pathogenic infections, our findings identify theSpry1 andSpry2 loci as attractive targets for increasing the number, survival, and function of antigen-specific memory CD8+ T cells. This may provide an opportunity for better future engineering of T cells against tumors and chronic viral infections.

Lack of Sprouty 1 and 2 enhances survival of effector CD8 + T cells and yields more protective memory cells

Lack of Sprouty 1 and 2 enhances survival of effector CD8 ⁺ T cells and yields more protective memory cells