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Significance These studies provide mechanistic insights into the nature of in vitro-generated iPSC-derived myogenic progenitors and, importantly, what these cells become upon engraftment. The fact that iPSC-derived myogenic progenitors remodel their embryonic/fetal molecular signature upon in vivo exposure to the adult muscle environment has important implications for therapeutic applications, as attested by their robust and persistent regenerative potential.

Pluripotent stem cell-derived myogenic progenitors remodel their molecular signature upon in vivo engraftment