English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Mosquitoes pose an enormous threat to humans by transmitting numerous dangerous diseases. To become reproductively competent and effective disease vectors, it is crucial for them to achieve optimal body size and nutritional status. Elucidation of these processes in mosquitoes has been hampered by the lack of classic genetics tools. CRISPR-Cas9 disruption of the fat-body–specific serotonin receptorAa5HT2B impairs body growth and lipid accumulation inAedes aegypti mosquitoes, the vectors of dengue fever, yellow fever, and Zika virus. Aa5HT2B controls insulin-like peptides. Using the CRISPR-Cas9 approach, we have uncovered differential roles of insulin-like peptides in the control of body size and metabolism, and provided a link between blood feeding and the fat-body–specific serotonin signaling.

Serotonin signaling regulates insulin-like peptides for growth, reproduction, and metabolism in the disease vector Aedes aegypti